USMLE Test Sampler Questions 1 - 10

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1. A 32-year-old construction worker arrives in the emergency department after an accident on the job. The tendon of the biceps brachii at the elbow has been severed by a laceration that extends 2 cm medially from the tendon. Which of the following structures is likely to have been injured by medial extension of the laceration?

(A) Brachial artery
(B) Musculocutaneous nerve
(C) Profunda brachii artery
(D) Radial nerve
(E) Ulnar nerve
Answer 1


2. A genotypic male (XY) is born with feminized external genitalia. The testes are retained within the abdominal cavity, and the internal reproductive tracts exhibit the normal male phenotype. Which of the following could account for this abnormal development?

(A) Complete androgen resistance
(B) 5a-reductase deficiency
(C) 17a-hydroxylase deficiency
(D) Sertoli-only syndrome
(E) Testicular dysgenesis
Answer 2


3. A 24-year-old AIDS patient develops chronic abdominal pain, low-grade fever, diarrhea, and malabsorption. Oocysts are demonstrated in the stool. Which of the following organisms is most likely to be the cause of the patient’s diarrhea?

(A) Diphyllobothrium latum
(B) Entamoeba histolytica
(C) Giardia lamblia
(D) Isospora belli
(E) Microsporidia
Answer 3


4. A 28-year-old man decides to donate a kidney to his brother, who is in chronic renal failure, after HLA typing suggests that he would be a suitable donor. He is admitted to the hospital, and his right kidney is removed and transplanted into his brother. Which of the following indices would be expected to be decreased in the donor after full recovery from the operation?

(A) Creatinine clearance
(B) Creatinine production
(C) Daily excretion of sodium
(D) Plasma creatinine concentration
(E) Renal excretion of creatinine
Answer 4

5. Bilateral ovarian masses are identified on pelvic examination of a 40-year-old woman. Ultrasound examination reveals multiloculated cystic masses involving both ovaries. The patient is treated with total abdominal hysterectomy with removal of both adnexa. Pathologic examination demonstrates papillary carcinoma producing serous fluid. Which of the following tumor markers would be most useful in monitoring for recurrence?

(A) Alpha-fetoprotein
(B) Bombesin
(C) CA-125
(E) S-100
Answer 5

6. In a normal individual, a tube with a transducer at its tip is swallowed and passed an unknown distance down the esophagus. Between swallows it records a pressure of 25 mm Hg. A small amount of water is swallowed. Within 2 seconds, the pressure falls to 5 mm Hg, where it remains until returning to its resting pressure 6 seconds later. In a patient with achalasia, the transducer is advanced to the same location. Between swallows, it records a pressure of 30 mm Hg. After swallowing, the pressure fails to decrease at all. In which of the following sites is the transducer most likely located?

(A) Esophageal body distal to the diaphragm
(B) Esophageal body proximal to the diaphragm
(C) Lower esophageal sphincter
(D) Pharynx
(E) Upper esophageal sphincter
Answer 6

7. A 54-year-old man with extensive, severe atherosclerosis sustains a thrombotic occlusion of the celiac trunk. The organs that receive their blood supply from this artery continue to function normally. Anastomoses between which of the following pairs of arteries would explain this phenomenon?

(A) Left gastric artery and right gastric artery
(B) Left gastroepiploic artery and right gastroepiploic artery
(C) Proper hepatic artery and gastroduodenal artery
(D) Right colic artery and middle colic artery
(E) Superior pancreaticoduodenal artery and inferior pancreaticoduodenal artery
Answer 7

8. A 54-year-old man presents to the emergency department with intense pain in his right eye. Examination reveals a red ring surrounding his iris and elevated intraocular pressure in the same eye. After obtaining a careful history with the aid of the man’s wife, the emergency room physician concludes that this episode was triggered by which of the following agents?

(A) Amitriptyline
(B) Cimetidine
(C) Diazepam
(D) Malathion
(E) Propranolol
Answer 8

9. While lying supine in bed eating, a child aspirates a peanut. Which of the following bronchopulmonary segments would this foreign object most likely enter?

(A) Apical segment of the left upper lobe
(B) Apical segment of the right upper lobe
(C) Medial segment of the right middle lobe
(D) Posterior basal segment of the left lower lobe
(E) Posterior basal segment of the left lower lobe
Answer 9

10. A 47-year-old man with a history of sickle cell disease has had numerous hospitalizations requiring the placement of IV lines. The patient has poor peripheral venous access, and a catheter is placed in right subclavian vein. The patient subsequently develops right arm discomfort and swelling and a temperature of 40.1 C with chills. Multiple blood cultures are taken, and gram-positive cocci are isolated. The organism is catalase positive and grows on mannitol salt agar, but does not turn the agar yellow; the colonies are gamma-hemolytic on a sheep blood agar plate. Which of the following organisms is the most likely cause of this patient’s symptoms?

(A) Enterococcus faecalis
(B) Staphylococcus aureus
(C) Staphylococcus epidermidis
(D) Streptococcus agalactiae
(E) Streptococcus pyogenes
Answer 10

Continue on to USMLE practice questions block 2.

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