USMLE Answer 31

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31. The correct answer is B. Nodular lymphomas of all types are derived from the B-cell line. The translocation t(14, 18), with bcl-2 activation, is associated with these lymphomas.

An abl-bcr hybrid (bcr-c-abl; choice A) and t(9, 22) translocation (choice E) are associated with chronic myeloid leukemia (CML).

c-myc activation (choice C) and t(8, 14) (choice D) are associated with Burkitt lymphoma.