Medical Student

USMLE Practice Questions

USMLE Practice Questions

Get the most comprehensive USMLE Step 1 Prep available with Kaplan Medical. Enroll Today!

Click on the links at the top of each section for complete questions and answers.

USMLE Practice Questions 1 – 10

1. A 32-year-old construction worker arrives in the emergency department after an accident on the job.

2. A genotypic male (XY) is born with feminized external genitalia.

3. A 24-year-old AIDS patient develops chronic abdominal pain, low-grade fever, diarrhea, and malabsorption.

4. A 28-year-old man decides to donate a kidney to his brother, who is in chronic renal failure

5. Bilateral ovarian masses are identified on pelvic examination of a 40-year-old woman.

6. In a normal individual, a tube with a transducer at its tip is swallowed and passed an unknown distance down the esophagus.

7. A 54-year-old man with extensive, severe atherosclerosis sustains a thrombotic occlusion of the celia trunk.

8. A 54-year-old man presents to the emergency department with intense pain in his right eye.

9. While lying supine in bed eating, a child aspirates a peanut.

10. A 47-year-old man with a history of sickle cell disease has had numerous hospitalizations requiring the placement of IV lines.

USMLE Practice Questions 11 – 20

11. A 2-month-old child is evaluated for failure to thrive. During the examination, the child has a seizure.

12. The parents of a 7-year-old boy divorce.

13. A letter carrier is severely bitten by a pit bull guarding a junkyard.

14. A 25-year-old man presents to a rheumatologist with complaints of joint pain involving the large joints of the legs.

15. A couple has a daughter who is ataxic and has a seizure disorder.

16. A 65-year-old man develops oliguria and peripheral edema over a period of weeks.

17. A 75-year-old woman presents to the physician with a chief complaint of vaginal spotting.

18. A neonate does not pass meconium until 48 hours after his birth.

19. A 2-year-old child with uncomplicated coarctation of the aorta appears to be in good health.

20. A 75-year-old man presents to his physician with complaints of nocturia, urinary urgency

Questions 21 – 30

21. An adult patient presents with persistent headaches. A CT scan of the head demonstrates a 2-cm spherical mass

22. A 37-year-old woman presents to the emergency department with a fever. Chest x-ray film shows multiple patchy

23. A 5-year-old child, who has not had routine pediatric care, develops a febrile disease with cough and a blotchy rash and is brought to the emergency department.

24. A 57-year-old man is brought to the emergency room for a suspected myocardial infarction. An electrocardiogram indicates the appearance of a wide-complex ventricular tachycardia…

25. While performing a subtotal thyroidectomy, a surgeon inadvertently sections the recurrent laryngeal nerve.

26. A newborn infant who was apparently healthy at birth develops aspiration pneumonia in the first 2 days of life

27. A 46-year-old man sustains a spider bite on his upper eyelid, and an infection develops.

28. A 15-year-old high school student and several of her friends ate lunch at a local Chinese restaurant.

29. A 24-year-old woman with a history of allergic rhinitis is involved in an automobile accident and sustains a splenic laceration

30. A couple presents to a clinic for workup of infertility after 5 years of unprotected intercourse.

USMLE Practice Questions 31 – 40

31. A patient presents with cervical lymphadenopathy.

32. A 25-year-old woman presents with pain and tenosynovitis of the wrists and ankles, and arthralgias of other joints.

33. A 5-year-old girl is thoroughly evaluated because of growth failure.

34. A new antifungal medication is being tested in Phase I clinical trials. Examination of the pharmacokinetic properties of the drug reveals..

35. A patient presents to a physician with jaundice. Physical examination reveals a nodular, enlarged liver.

36. A man brings his 45-year-old wife to the emergency department. He states she has been ill for 3 days

37. A patient consults a physician because of a small lesion on the lips that, on biopsy, proves to be a mucosal neuroma.

38. A 2-year-old boy has a CT scan of the head performed after a pediatrician notices a disproportionate growth

39. A premature infant develops progressive difficulty breathing over the first few days of life.

40. A 67-year-old woman who has been in very good health is brought to her physician’s office by her husband.

Questions 41 – 50

41. A 57-year-old woman with a history of hypertension and arthritis is referred to a rheumatologist for evaluation.

42. A 55-year-old hypertensive man develops sudden onset of excruciating pain beginning in the anterior chest, and then radiating to the back.

43. A 22-year-old woman presents to her physician with amenorrhea, weight loss, anxiety, tremor, heat intolerance, and palpitations.

44. A 54-year-old African-American woman undergoes a routine insurance physical examination.

45. A 67-year-old man is evaluated for persistent shooting pains, lower limb ataxia, and bladder dysfunction.

46. An oncologist tells his patient that her laboratory results support a diagnosis of advanced malignant melanoma with multiple metastases to the liver and brain.

47. A 44-year-old businessman presents to a physician because of a markedly inflamed and painful right great toe.

48. A Guatemalan child with a history of meconium ileus is brought to a clinic because of a chronic cough.

49. During a fight, a 32-year-old man is hit on the back of the neck with a chair.

50. A 61-year-old man presents with a chief complaint of difficulty swallowing.

USMLE Practice Questions 51 – 60

51. The table below depicts blood pressure values taken from six adults. Which set of values is most consistent with aortic regurgitation?

52. In a hospital cardiac care unit, there are three patients with different cardiac conditions

53. A 68-year-old man sustains a myocardial infarct resulting from thrombotic occlusion at the origin of the left circumflex artery.

54. A patient arrives in the emergency department after having been stabbed.

55. A 14-year-old boy has just moved with his family from Brazil to the U.S.

56. A 65 year-old man is admitted to the coronary care unit with a diagnosis of a large myocardial infarct (MI) of the left ventricle.

57. A 15-year-old is brought to the emergency department in a coma.

58. A 24-year-old woman in her third trimester of pregnancy presents with urinary frequency and burning for the past few days.

59. A 12-year-old girl has a temperature of 102.5 F and a sore throat.

60. A 45-year-old man with cirrhosis due to alpha1-antitrypsin deficiency receives a liver transplant.